Medical sector has always been enthusiastic when it comes to development of new medical miracles. In a similar experimentation, the team has been successful in developing lungs that have been grown inside the lab to be transplanted into the bodies of pigs. This particular breakthrough has opened up various possibilities for these bio-engineered lungs to be implanted in humans.
Joan Nichols, Associate Director at Galveston National Laboratory from the University of Texas Medical Branch said that this was the first instance for the medical industry to have bioengineered a fully functional bioengineered organ. He further added that the experiment also showcased an amazing growth in the tissues along with accelerated development of vascular system. The transplant worked perfectly with no infection or tissue rejection. The transplanted lung worked perfectly inside the animal.
In order to prepare the lungs a scaffold was created by the researchers from some unrelated pig donor. This process was initiated with the help of a process that removed all the blood and cells from the said organ with just a skeleton left. The cell source was extracted from another pig that was required for the bioengineered lung with matching tissue for successful transfer.
A total of 6 such lungs were bioengineered to be transplanted. However, only 4 of them were able to go through transplantation procedure due to some surgical issues. There was a continuous growth noticed in the animals that received the transplant with a substantial growth factor that helped the cells in surviving inside the body. The scientists also said that they made sure every necessary cell was added to initiate proper development of the lungs which includes the blood vessel cells, vascular cells, and lung-specific cells to be present inside the scaffold with proper location of each inside the lungs.
The previous accomplishments of the team included findings that suggested that it was possible for the medical community to produce lungs that are capable of being used by humans post placement with surgery. However, the team suggested that clinical trials would require more tests to be done for 5 to 8 years to ensure that human trials go without any kind of failure. However, if everything goes fine, this particular event could remove the word limit from the medical dictionary and create endless possibilities while saving countless lives. The achievements and details of the work was published in the journal named Translational Medicine.